Publications

Full pulblication list in ORCID and Google Scholar

  1. Xiang W, Lu H, Shen A, Ni H, Wang Y. Nuclear β-adrenergic signaling microdomain alleviates diabetic kidney fibrosis by YAP inactivation. British Journal of Pharmacology (In revision).

  2. Wang Y, Zhao M, Liu XH, Xu B, Rivera G, Xiang YK. Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac contractility in Heart failure. JACC: Basic to Translational Science (Accpted).

  3. Fu Q, Wang Y, Yan C, Xiang YK. Phosphodiesterases in heart and vessels- From Physiology to Diseases. Physiol Rev. 2023.

  4. Bing Xu, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yu Zhang, Bingqing Deng, Zhenduo Zhu; Qiuyun Guan, Nipavan Chiamvimonvat, Qingtong Wang, and Yang K. Xiang. Differential downregulation of subcellular specific beta1-adrenergic receptor signaling in the heart. Journal of the American Heart Association (Accpted).

  5. Wenjing Xiang1*, Xingyun Wang1*, Lei Li1, Junhui Zeng1, Haocheng Lu1&, Ying Wang1&, Unveiling Catecholamine Dynamics in Cardiac Health and Disease: Mechanisms, Implications, and Future Perspectives. International Journal of Drug Discovery and Pharmacology 2023.

  6. Xiang W, Zhou N, Li L, Chen F, Li L, Wang Y. βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases. Comment on Nassal et al. Spectrin-Based Regulation of Cardiac Fibroblast Cell-Cell Communication. Cells 2023, 12, 748. Cells. 2023;12:2186.

  7. Deng BQ*, Zhang Y*, Zhu CQ*, Wang Y, Weatherford E, Xu B, Conway S, Abel ED, and Xiang YK. Divergent actions of myofibroblast and myocyte beta2-adrenoceptor signaling in heart failure and fibrotic remodeling. Circ Res. 2022 Dec; DOI: 10.1161/CIRCRESAHA.122.321816

  8. Lu, H., Zhang, C., Li, Y. and Wang, Y. (2022), Mitochondria dysfunction in the failing right heart: what is the potential therapeutic target?. J Physiol. Accepted Author Manuscript. https://doi.org/10.1113/JP283977

  9. Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022;117:37

  10. Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure. Circ Res. 129 (10), 965-967.

  11. Wang Y*, Shi Q*, Li M, Zhao M, Reddy GR, Teoh JP, Xu B, Zhu CQ, Ireton KE, Srinivasan S, Chen SL, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. Intracellular β1-Adrenergic eceptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2020 Nov; DOI: 10.1161/CIRCRESAHA.120.317452.

  12. Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK. Carvedilol induces biased β1 adrenergic receptor-Nitric oxide synthase 3-cyclic guanylyl monophosphate signaling to promote cardiac contractility. Cardiovasc Res. 2020 Sep 21; doi: 10.1093/cvr/cvaa266.

  13. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. GRK5 Controls SAP97-Dependent Cardiotoxic β1 adrenergic receptor-CaMKII signaling in heart failure. Circ Res. 2020 Aug 28;127(6):796-810. doi: 10.1161/CIRCRESAHA.119.316319.

  14. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 Nov 5;150(11):1567-1582. doi: 10.1085/jgp.201812119.

  15. Wang Y, Cao Y, Zhu Q, Gu X, Zhu YZ. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 2016 Jul 22;6:29820.

  16. Wang Y, Zhong L, Liu X, Zhu YZ. ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing nox4-derived ROS production and apoptosis. Molecules. 2017 Feb 21;22(2). doi: 10.3390/molecules22020331.aax8286. doi: 10.1126/sciadv.aax8286. PMID: 32064340; PMCID: PMC6989145.

  17. Wang Y, Zhang Q, Zhong L, Lin M, Luo X, Liu S, Xu P, Liu X, Zhu YZ. Apoptotic Protease activating factor-1 inhibitor mitigates myocardial ischemia injury via disturbing procaspase-9 recruitment by Apaf-1. Oxid Med Cell Longev. 2017;2017:9747296.

  18. Zhang QY, Wang ZJ, Miao L, Wang Y, Chang LL, Guo W, Zhu YZ. Neuroprotective Effect of SCM-198 through stabilizing endothelial cell function. Oxid Med Cell Longev. 2019;2019:7850154.

  19. Zhang QY, Wang ZJ, Sun DM, Wang Y, Xu P, Wu WJ, Liu XH, Zhu YZ. Novel Therapeutic effects of leonurine on ischemic stroke: New Mechanisms of BBB Integrity. Oxid Med Cell Longev. 2017;2017:7150376.

  20. Xu B, Wang Y, Bahriz SMFM, Zhao M, Zhu C, Xiang YK. Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes. Cell Commun Signal. 2022 Sep 14;20(1):143.